Adamantium is an indestructable metal used in many people for experiments.
Stryker and the Weapon X team then proceeded to inject the adamantium into the skeleton and bone-claws of Wolverine making him indestructible. When he is later shot in the head with bullets made of the compound, he sustained severe intra-cranial trauma that induced extensive amnesia.
Later on, Wolverine's memories began to return to him, and by the time of the events that occured in The Wolverine, he managed to regain much of his lost memories.
Sabretooth wanted to be in the experiment that his brother was in. Stryker said he couldn't survive and rejected the deal after Sabretooth did what was asked.
Stryker later gave similar claws to Lady Deathstrike, his controlled bodyguard, extruding from the tips of her fingers. However, in a battle with Wolverine, he defeated her when he impaled her with an adamantium needle which pumped her body full of the indestructible alloy and she fell to the bottom of the Weapon X tank.
When Ichirō Yashida became ill and on the verge of death, he began stockpiling adamantium reserves at his facility in the north of Japan to construct the Silver Samurai armour as a life support system in the interim period before Wolverine was captured. He ordained the capture of Wolverine so that he could cut through Logan's adamantium claws using a heated adamantium blade and distill Logan's healing powers into his own body to live forever.
The katana that the Yashida Clan had within their possession in their household were also likely made out of adamantium, as it has been proven that regular adamantium cannot cut adamantium.
- Although William Stryker stated in X2: X-Men United that adamantium became indestructible once it cooled, it has been proven that, if adamantium weapons are super-heated they are capable of damaging other adamantium weapons, i.e. cutting off Wolverine's adamantium claws.