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|Leader(s)|| William Stryker|
|Movie||X2: X-Men United|
|Game||X-Men: The Official Game|
|Comic|| X2: X-Men United: The Movie Prequel: Nightcrawler|
X2: X-Men United: The Movie Prequel: Wolverine
|Base of Operation(s)||Alkali Lake|
- HYDRA also appeared in Marvel Cinematic Universe's Captain America: The First Avenger, Captain America: The Winter Soldier, Avengers: Age of Ultron, and Marvel's Agents of S.H.I.E.L.D. as a major antagonistic organization. And the leader is Red Skull.
- This version of HYDRA closely resembles the 616 version of the Purifiers, a paramilitary organization co-ordinated by Reverend William Stryker dedicated to hunting down mutants in the name of God. The Purifiers were first introduced in the X-Men graphic novel "God loves, Man kills", the comic that X2 was loosely based on.
- In the comics, Bob is an agent of HYDRA.