Lady Deathstrike appears in the video game X2: Wolverine's Revenge.
She is a minor boss who duels with Wolverine near the end of the game until Wolverine knocks her off the building. She hits the ground and is knocked unconscious. Sabretooth later comes to retrieve her, after taking a vial from her unconscious body to cure himself.
The version of Lady Deathstrike in this video game bears resemblance to the Lady Deathstrike in X2: X-Men United, with a leather jacket, black hair and adamantium craws, but has a different face and has two tattoes on both of her cheeks.