|Appeared in||X-Men Origins: Wolverine|
Schreiber had several supporting roles in various independent films until his big break, as the accused murderer Cotton Weary in the Scream trilogy of horror films. Though the success of the Scream trilogy would lead Schreiber to roles in several big-budget studio pictures, Entertainment Weekly wrote in 2007 that "Schreiber is [still] best known for such indie gems as Walking and Talking, The Daytrippers, and Big Night.
After Scream, Schreiber was cast as the young Orson Welles in the HBO original movie RKO 281, for which he was nominated for Emmy and Golden Globe Awards. He then played supporting roles in several studio films, including the 2000 movie of Hamlet with Ethan Hawke, The Hurricane with Denzel Washington, and The Sum of All Fears with Ben Affleck. The 2004 remake of The Manchurian Candidate, with Washington and Meryl Streep, was another major film for the actor, stirring some controversy as it opened during a heated presidential election cycle. Schreiber also played Robert Thorn with Julia Stiles in the 2006 film The Omen, a remake of the 1976 horror classic The Omen (1976). Shreiber's character is an American ambassador who learns to his horror that his son is actually the literal Antichrist. He played the time-traveling ex-boyfriend of Meg Ryan in Kate and Leopold, with Hugh Jackman's century-old character, Leopold, having followed Liev into current times, playing the ultimate love interest of Meg Ryan's Kate.
Along with his screen work, Schreiber is a well-respected classical actor; in a 1998 review of the Shakespeare play Cymbeline, The New York Times called his performance "revelatory" and ended the article with the plea, "More Shakespeare, Mr. Schreiber." A year later, Schreiber played the title role in Hamlet in a December 1999 revival at The Public Theater, to similar raves. In 2000, he played Laertes in Hamlet, a modern adaptation of the play. His performance in the title role of Henry V in a 2003 Central Park production of that play caused Lahr to expound upon his aptitude at playing Shakespeare. "He has a swiftness of mind," Lahr wrote, "which convinces the audience that language is being coined in the moment. His speech, unlike that of the merely adequate supporting cast, feels lived rather than learned."
Schreiber has narrated a number of documentaries, many of them aired as part of PBS series such as American Experience, Nova, and Secrets of the Dead. He is also the voice behind the television commercials for Infiniti.
In 1994, he narrated Two Billion Hearts, the official film of 1994 World Cup.
Schreiber is also the voice of HBO's Sports of the 20th Century documentaries. Similarly, Schreiber is also the narrator of HBO Boxing's Countdown and 24/7 documentary series. Schreiber served as the voice of Skeletor in the 2002 incarnation of Masters of the Universe. Schreiber narrated Hard Knocks: Training Camp with the Cincinnati Bengals in 2009, and Magic & Bird: A Courtship of Rivals and Broad Street Bullies in 2010, on HBO. Schreiber provided the narration for "Making of Pumping Iron" documentary that is included in a special anniversary edition of the movie Pumping Iron. He also narrated the History Channel specials Ape to Man and America: The Story of Us.
Schreiber reprised his role as narrator for HBO's 24/7: Road to the Winter Classic NHL documentary, which followed the Pittsburgh Penguins and Washington Capitals as they prepared to face each other in the 2011 NHL Winter Classic at Heinz Field, in Pittsburgh, Pennsylvania on January 1, 2011. Washington won 3-1.
Schreiber told The New Yorker in 1999 that "I don't know that I want to be an actor for the rest of my life." For a time in the late nineties, he hoped to produce and direct an adaptation of The Merchant of Venice starring Dustin Hoffman. In that time, Schreiber started writing a screenplay about his relationship with his Ukrainian grandfather, a project he abandoned when, according to The New York Times, "he read Jonathan Safran Foer's hit novel, Everything Is Illuminated, and decided Mr. Foer had done it better." Schreiber's film adaptation of the short story from which the novel originated, which he both wrote and directed, was released in 2005. The film, which starred Elijah Wood, received lukewarm-to-positive reviews, with Roger Ebert calling it "a film that grows in reflection."
In 2002, he starred in Neil LaBute's play The Mercy Seat along with Sigourney Weaver on Off-Broadway that was critically and commercially very successful. In the spring of 2005, Schreiber essayed the role of Richard Roma in the Broadway revival of David Mamet's Pulitzer Prize-winning play Glengarry Glen Ross. As Roma, Schreiber won a Tony Award for Best Performance by a Featured Actor in a Play.
In 2006, Schreiber was invited to join the Academy of Motion Picture Arts and Sciences. In fall of that year, Schreiber directed and starred in the "2006 Join the Fight" AIDS PSA campaign for Cable Positive and Kismet Films (others involved with the campaign included actress Naomi Watts, fashion designer Calvin Klein, and playwright Tony Kushner).
Schreiber played Charlie Townsend in the 2006 film The Painted Veil, starring opposite Watts and Edward Norton. In the same year, Schreiber also appeared in The Omen, which was a remake of the 1976 film of the same name. For television, the actor portrayed a character who temporarily replaces Gil Grissom, played by William Petersen, in the CBS show CSI: Crime Scene Investigation, during the 2006–2007 season. He played Michael Keppler, a seasoned CSI with a strong reputation in various police departments across the nation, before joining the veteran Las Vegas team. Schreiber joined the cast on January 18, 2007 and shot a four-episode arc.
Schreiber appeared in the Broadway revival of Eric Bogosian's Talk Radio. The show began previews at the Longacre Theatre on February 15, 2007 in preparation for its March opening. On May 11, 2007, He won the Drama League Award for distinguished performance for his portrayal of shock jock "Barry Champlain" in Talk Radio, and has received Tony, Drama Desk, and Outer Critics Circle Award nominations for the role. The New York Times' Ben Brantley called his performance "the most lacerating portrait of a human meltdown this side of a Francis Bacon painting."
Schreiber played the womanizing Lotario Thurgot in Mike Newell's screen adaptation of Love in the Time of Cholera, released in 2007. In a January 2007 interview, Schreiber mentioned that he was working on a screenplay.
Late in 2008, Schreiber portrayed Jewish resistance fighter, Zus Bielski in the film Defiance, alongside Daniel Craig. In February 2008, 20th Century Fox announced Schreiber would play the mutant supervillain, Sabretooth in the Marvel Comics film X-Men Origins: Wolverine, released on May 1, 2009. In March 2010, it was announced that he is interested in returning for Scream 4, portraying Cotton Weary a fourth time (the film was made without his involvement).