|Appeared in||X-Men Origins: Wolverine|
Collins was born in Houston, Texas. She attended the Juilliard School for Drama and has had experience on both stage and screen in Shakespearean roles. In 2004, she played the role of Portia in the critically well-received film The Merchant of Venice, based on Shakespeare's play, starring opposite Al Pacino, Joseph Fiennes and Jeremy Irons.
In 2010, Collins filmed Unconditional  in Nashville, Tennessee, playing Sam. The film is directed by Brent McCorkle and was originally titled "Firebird". She also played Dejah Thoris in the film John Carter.
In 2006, Collins began dating actor Steven Strait. Strait announced the couple's engagement in 2008, and the two were later married.