At some point, Ryan Reynolds was featured on a cover of People Magazine. Deadpool would later make fun of the actor's career.
- Ryan Reynolds is one of the few actors to play a character in both a Marvel comics film and a DC Comics film. He subsequently played Hal Jordan/The Green Lantern in 2011's Green Lantern. Prior to playing Deadpool, Reynolds also played Hannibal King in Blade Trinity. His role as Green Lantern is referenced in Deadpool when Wade asks for his suit not to be made green or animated. Wade also later mentions Reynolds by name in the film.
- Ryan Reynolds also portrayed Nick Walker in the comic book adaptation R.I.P.D. with Kevin Bacon.
- Surprisingly, Ryan Reynolds reprises his role as Deadpool for the Honest Trailer of Deadpool.
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