Warren Worthington II is the head of Worthington Labs, the corporation that developed the mutant "cure".
Around 1996, Warren Worthington II walked in on his son cutting his wings off in the bathroom. Seeing his son as a mutant caused him to be ashamed. Ten years after that, around 2006, he managed to create a mutant cure. He was going to use it first on his son, but Warren III/Angel escaped before it could be used on him. When Psylocke, Quill and Arclight were going to kill him, they pushed him off the roof; however, he was saved by his son.
- It isn't clear if the Angel in X-Men: Apocalypse (which takes place in the revised timeline) is Warren Worthington II's son, as he is located in Berlin and part of a fight club.